Acute lethal toxicity following passive immunization for treatment of murine cryptococcosis

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Acute lethal toxicity following passive immunization for treatment of murine cryptococcosis.

Passive immunization with monoclonal antibodies (MAbs) specific for the major capsular polysaccharide of Cryptococcus neoformans alters the course of murine cryptococcosis. During studies of passive immunization for treatment of murine cryptococcosis, we noted the occurrence of an acute, lethal toxicity. Toxicity was characterized by scratching, lethargy, respiratory distress, collapse, and dea...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 1997

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.65.5.1800-1807.1997